2/15/2023 0 Comments I doser doses giftingWeight-based dosing is also a cause for potential medication errors. Hence, obesity may affect loading dose, dosage interval, plasma half-life, and time to reach steady-state concentration for various medications. They may also experience decreased hepatic clearance secondary to fatty infiltrates of the liver. Conversely, the Vd of hydrophilic medications may be increased or decreased due to increased lean body mass, blood volume, and decrease percentage of total body water. Obese individuals generally have a larger volume of distribution for lipophilic medications. This creates significant challenges to dosing medications that are primarily weight based (mg/kg) and in predicting pharmacokinetics parameters in pediatric patients. children ages 2 to 19 years are considered overweight or obese.
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